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KMID : 0378019820250050059
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New Medical Journal
1982 Volume.25 No. 5 p.59 ~ p.66
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Clinical Observation of Acute Transformation in Chronic Myelocytic Leukemia
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Abstract
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44 patients with chronic myelogenous leukemia in terminal phase (accelerated phase & blast crisis) were evaluated in their clinical characteristics and response to treatment.
Their median survival time was 31 months from diagnosis and 2 months from blast crisis. Median duration from diagnosis to accelerated phase wa´s 23 months, and 3 months from accelerated phase to blast crisis.
Of 23 expired patients, seven patients(30%) progressed to blast crisis without acceled rated phase and another seven patients(30%) died in accelerated´ phase without progres￢sion to blast crisis.
Their clinical characteristics are as follows: fever (64%), inexplicable malaise (83%), anemia (94%), leukocytosis(55%) and thrombocytopenia (69%). But no significant difference was observed between accelerated phase and blast crisis.
Eight patients in accelerated phase were treated with hydroxyurea. Of the 8 patients, one patient showed complete remission and partial remission obtained ´in 5 patients. Median duration of accelerated phase in hydroxyurea-treated group (7 months) was longer than that of untreated group (2 months). (p<0.05)
Fourteen patients in blast crisis were treated with Vincristine and Prednisone, of which four patients showed partial remission. Median survival of non-responders was 1 month which showed no difference from that of the untreated group. Of the four patients who showed response, two died in 3 months, one in 8 months and another one is still alive for 7 months.
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